Can Hydrogen Therapy Support Lung Cancer Treatment

What The Medical Journals Are Saying!

Lung Cancer is a serious condition that needs medical attention, and by no means should this blog post counter any medical advice. Yet medical evidence is showing that hydrogen therapy can support in the treatment of lung cancer, and below we have copied and pasted some key points from medical journals below.

Copied & Pasted from Medical Journals

Lung cancer is one of the most common lethal malignancies, with a poor prognosis owing to its high metastatic potential and drug resistance. An increasing number of animal experiments and clinical trials have established the efficacy of hydrogen against cancers, including lung cancer. The mechanisms underlying the anti-cancer effects of hydrogen are summarized as follows.

Hydrogen downregulates the expression of proteins involved in stemness, proliferation, and angiogenesis and upregulates the expression of proteins that promote differentiation (). Hydrogen can also downregulate the chromosome condensation regulator structural maintenance of chromosomes 3 (SMC3), as well as the migration and invasion of A549 and H1975 cells, thereby inhibiting lung cancer progression ().

Hydrogen modulates cell death. The dysregulation of apoptosis is a hallmark of cancer. The alteration of apoptosis contributes not only to tumor development and progression, but also to tumor resistance to therapies (). Hydrogen promotes apoptosis, including early and late apoptosis, in lung cancer (). The PI3K/Akt pathway is an important signaling pathway involved in extracellular signaling events and cellular processes, including cell proliferation, apoptosis, and survival. In non-small cell lung cancer, when combined with the PI3K inhibitor LY294002, hydrogen reduced cell proliferation and promoted apoptosis by downregulating Akt phosphorylation and inhibiting the PI3K pathway. Recently, it has been shown that hydrogen pretreatment enhances ROS and the expression of pyroptosis-related proteins, stimulates NLRP3 inflammasome/gasdermin D (GSDMD) activation, and inhibits endometrial cancer (). Further studies are needed to determine whether hydrogen can induce pyroptosis in lung cancer and to clarify the underlying molecular mechanism.

Hydrogen modulates immunity by reducing the proportion of terminal programmed cell death 1 positive (PD-1+‍) cluster of differentiation 8 positive (CD8+) T cells, which are associated with a poor prognosis in cancer (). In patients with lung cancer, hydrogen can activate coenzyme Q10, restore exhausted CD8+ T cells (especially PD-1+Tim3+ terminal CD8+ T cells; Tim3+‍, T cell immunoglobulin and mucin domaincontaining protein 3 positive), enhance the clinical efficacy of nivolumab, and increase overall survival time ().

Hydrogen can alleviate the side effects of conventional anti-cancer therapies, such as chemotherapy and radiotherapy, and improve quality of life. By reducing oxidative stress and inflammation, hydrogen protects cultured cells and mice against radiation-induced injury (). It also attenuates the gefitinib-induced exacerbation of naphthalene-induced ALI without impairing anti-tumor activity ().

Hydrogen is well-suited for the treatment of advanced cancer. It significantly improves the physical status of patients, reduces fatigue, insomnia, anorexia, and pain, and decreases elevated tumor markers. These effects are particularly evident in patients with lung cancer (). As a simple, low-cost treatment with few adverse reactions, hydrogen therapy in lung cancer is very promising.

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