What Is Parkinsons Disease?
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement. It’s characterized by the loss of dopamine-producing neurons in the brain, leading to symptoms like tremors, rigidity, slow movement, and postural instability. While the exact cause of PD remains unknown, it’s believed that, forever chemicals in tap water, heavy metals, air pollution, micro plastics, lifestyle habits factors, such as poor sleep, over stress, a diet high in sugar, ultra processed foods and seed oils may contribute to the condition, as all of these put more strain on the cell in producing more oxidative stress and harmful free radicals for the body. Millions worldwide are affected by this debilitating condition, and the quest for effective prevention strategies is ongoing, yet the overload of oxidative stress on the cell may be part of the early pathway to developing Parkinsons.
Statics
The average age in being diagnosed with Parkinson is between 60 to 70 years old. There are over 165, 000 people diagnosed with Parkinsons in the UK, with around 17,000 new cases each year. There are around 15, 000 cases of early on set Parkison’s between the age of 30 to 50 years old. If someone has a specific gene such as LRRK2, SNCA or GBA these genes are linked to the likelihood of getting Parkinson´s, this is around 5% of people who get Parkinson´s, yet 95% of people who do develop Parkinsons, it may be due to some of the factors we highlight in this blog.
ROS & Oxidative Stress
Downstream of the equation is Parkinsons. Upstream of the equation is what possibly causes Parkinson's and what are things that can possibly help prevent Parkinson's developing. Inside the cell are mitochondria's that turn food into fuel called ATP, in the process of making ATP there are 11 steps. Just as in a car running on petrol there is a waste product. In the cell the waste product is ROS or Oxidative Stress. The body has a natural way to deal with ROS which is antioxidants, such as the body makes Glutathione, SOD and we can consume antioxidants such as Vitamin C / E, Q10 to Flavonoids. All of these mop up ROS.
Here is the BUT, when the body is overburdened with substances that causes a higher rate of oxidative stress, the problem starts building up. The obvious substances that add a load are ultra processed foods, smoking, alcohol, seed oils, over consummation of sugar, forever chemicals from tap water or fry pans, air pollution, micro plastics and some pharmaceutical drugs.
Once the cell is starting to get over burden with oxidative stress, the following starts to happen, it starts to either shut down or not work as well, in this process, the cell struggles to turn glucose into ATP, which means there will be more free floating glucose and insulin in the blood stream, which then can get stuck in different parts of the body and can cause fatty liver. Also inside the cell is a protein called APP which when inside the cell helps with neuronal development and function, particularly synaptogenesis, synaptic plasticity, and cell growth. Yet this APP needs ATP to stay inside the cell, when the cell starts to lose energy, this APP protein starts to get fragmented and displaced into the blood system this can cause amyloid plaque in the brain, which then starts to block synaptic pathways, and this will accelerate cognitive decline. This is not the primary hallmark of Parkinson's, yet it is often part of the disease.
There is a saying prevention is better than the cure. In this case the cure does not exist, so even more it is worth looking at what can possibly prevent Parkinson's developing, having a healthy lifestyle, with a low carb diet, good omega oils, healthy fats, healthy cook wear, changing white sugar for monk sugar or Allulose, not having too much caffeine, prioritizing sleep, mediating, getting out in nature, avoiding junk food or processed foods , changing seeds oils for coconut oil or tallow. This all could make a significate different, and maybe there is not science completely backing this up at the moment, yet my commonsense logic is saying it makes sense to me, and I´m not waiting for the science to fully catch up. On top of this if you breathed in hydrogen or drank hydrogen water, this would be an extra helping hand to your cells in reducing oxidative stress.
You may say, you missed out as we age, everything declines, and yes that is another factor. My reply would be would you rather age gracefully and die quietly without a health issue, or the latter.
Hydrogen: A Promising Preventive Agent
Emerging research suggests that hydrogen (H₂) may hold promise as a preventive or mitigating agent for Parkinson’s disease. Hydrogen is a small, inert molecule with several potentially beneficial properties:
- Antioxidant Effects: Hydrogen can selectively neutralize harmful free radicals, which are thought to contribute to neuronal damage in PD.
- Anti-inflammatory Properties: Inflammation plays a role in the progression of PD. Hydrogen can help reduce inflammation in the brain.
- Neuroprotective Effects: Studies have shown that hydrogen can protect neurons from damage and death.
While research is still in its early stages, several studies have shown promising results. For example, animal studies have demonstrated that hydrogen can protect against MPTP-induced neurotoxicity, a common model for Parkinson’s disease. Some clinical trials have also suggested that hydrogen-rich water may improve motor function and quality of life in individuals with PD. However, more extensive clinical trials are needed to confirm these findings and determine the optimal dosage and delivery methods.
Future Directions & Research
The potential of hydrogen as a preventive approach to Parkinson’s disease is an exciting area of research. Future studies should focus on:
- Large-scale clinical trials: To assess the efficacy and safety of hydrogen in preventing or mitigating PD.
- Optimal delivery methods: To determine the best way to administer hydrogen (e.g., hydrogen-rich water, inhalation).
- Combination therapies: To explore the potential benefits of combining hydrogen with other preventive strategies.
While hydrogen shows promise, it is important to consult with healthcare professionals before making any changes to your treatment plan. This blog post is for informational purposes only and does not constitute medical advice.
Conclusion
Parkinson’s disease poses significant challenges for prevention, but the potential of hydrogen as a neuroprotective agent offers a promising avenue for research. By neutralizing harmful free radicals such as ROS/Oxidative Stress, hydrogen can help keep the cell clean and help lower the risk or slow the progression of PD. Yet to highlight we believe this is only part of the picture, for a more robust approach to preventing Parkinson's, the other lifestyle suggestion, need to be considered to add to the equation.
Scientific Studies
Pilot study of H₂ therapy in Parkinson’s disease: a randomized double-blind placebo-controlled trial
Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases
Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice