Effect of Hydrogen on Sudden Deafness

In the past have need more research confirmed the hydrolysis hydrogen can effective treatment of deafness (hearing loss), however, most of the research is animal experiments, today to introduce the paper research is from Japan Ehime university school of medicine of human clinical experiments, also because of this, this study is very meaningful, let us continue to watch! Understanding of sudden deafness

According to the data of Taiwan, sudden deafness (Idiopathic sudden sensorineural hearing loss, ISSNHL) is defined as hearing loss at three consecutive sound frequencies within three days. It may be accompanied by tinnitus, ear swelling, headache, dizziness and other symptoms, the age of onset is mostly 4060 years old, men and women are equal, usually only on one side of the ear, few ears occur at the same time. So far, the cause of sudden deafness is still not quite clear, common may be due to viral infection, or due to the climate temperature, resulting in the blood circulation in the ear decreased, blood supply is insufficient, so sudden deafness is often known as “ear stroke”.

And according to a 2014 epidemiological statistics found that in Japan on average of 10 0000,60.9 people suffer from this disease, the present stage for sudden deafness treatment is many, including corticosteroids, hyperbaric oxygen therapy, vascular dilators, indoor steroid injection, etc., but although there are so many methods to treat, the prognosis of sudden deafness is still not ideal, about a third of the patients after treatment, still unable to recover. So, seeking new treatment has always been what medical staff try to find.

Hydrogen inhalation therapy for idiopathic sudden sensorineural deafness double-blind randomized controlled clinical trial of sudden deafness, full name is idiopathic sudden sensorineural deafness, clinical lack of ideal treatment of disease, hydrogen for hearing loss has many, here is hydrogen treatment of idiopathic sudden sensorineural deafness double-blind randomized controlled clinical trial, the results suggest that hydrogen has therapeutic effect on sudden deafness.

Hydrogen and ears
Background: Hydrogen (H2) has been reported to be effective for hearing loss in animal studies. However, no study has been conducted exploring the therapeutic effect of hydrogen on hearing loss in humans. Therefore, we conducted a double-blind randomized controlled trial to explore whether hydrogen is effective in treating idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: We conducted this double-blind randomized controlled trial in six hospitals between June 2019 and March 2022. The study protocol and trial registry have been published in the Clinical Trial Registry (jRCT, No. jRCTs06119004). We randomized ISSNHL patients into two groups, one with hydrogen therapy (group H2) and with air as placebo (control group). Hydrogen is treated by inhalation in combination with systemic corticosteroids and prostaglandin E1. The primary outcome was changes in hearing thresholds and hearing thresholds three months after treatment. Secondary outcomes included the proportion of patients with a good prognosis (complete recovery or significant improvement). Results: A total of 65 ISSNHL patients were included in the study (31 patients in the H2 group and 34 patients in the control group). The hearing threshold at three months after treatment was not significantly different between the two groups; 39.0 dB (95% confidence interval [CI]:28.7-49.3) in the H2 group and 49.5 dB (95% CI:40.3-58.7) in the control group. However, the change in hearing threshold at three months after treatment was 32.7 dB (95% CI:24.2-41.3) in the H2 group and 24.2 dB (95% CI:18.1-30.3) in the control group. Therefore, the change in hearing threshold in the H2 group was significantly better than that in the control group (P = 0.048).However, no adverse effects due to inhalation of hydrogen gas have been reported.
Figure: The proportion of complete recovery (red) varied significantly between the two groups, and the effect of hydrogen treatment was obvious. Conclusion: This is the first study to investigate the effect of hydrogen on ISSNHL treatment in humans. The results suggest that hydrogen therapy may be effective in ISSNHL treatment. Okada M, Ogawa H, Takagi T, Nishihara E, Yoshida T, Hyodo J, Shinomori Y, Honda N, Fujiwara T, Teraoka M, Yamada H, Hirano SI, Hato N.A double blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss. Front Neurosci.2022 Nov24; 16:1024634. The authors of this clinical research paper are from the Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Ehime University, Japan.2. Otolaryngology, Head and Neck Surgery Department, Ehime Prefecture Central Hospital, Matsuyama, Japan.3. Department of Otolaryngology, Xinju Bin Hospital, Japan.4, Department of Otolaryngology, Head and Neck Surgery, Ukashima Municipal Hospital, Japan.5 Takoko Matsuyama Hospital, Japan.6 Otolaryngology, Red Cross Hospital, Matsuyama City, Japan.7 Public Health Research, Kurashi Clinical Institute, Japan.8 Miz Company Limited RD, Kamakura, Japan.

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